Table 3, Table 4 present the results from the main effects multilevel growth models of HED as a function of PGSPAU and parental separation and discord for the EA and AA samples, respectively. All results indicated that there was linear and quadratic change in HED across time. Age was associated with these trajectories, with a positive slope, followed by a small negative quadratic effect. Being male was associated with a steeper increase over time with a small negative quadratic effect.Table 3Linear Mixed Models Predicting Frequency of Heavy Episodic Drinking Across Time as a Function of Problematic Alcohol Use Polygenic Scores, Parental Separation, and Parental Discord in the European American (EA) SampleParental separation modelParental discord modeln = 1,751 (observations = 8,262)n = 1,362 (observations = 6,600)Parameterb95% CIb95% CIAge I–0.563[–0.719, –0.406]–0.464[–0.603, –0.325] S0.383[0.341, 0.426]0.371[0.331, 0.412] Q–0.015[–0.017, –0.013]–0.015[–0.017, –0.013]Sex, male I–0.232[–0.432, –0.033]–0.189[–0.383, –0.006] S0.182[0.128, 0.236]0.176[0.118, 0.234] Q–0.007[–0.009, –0.004]–0.006[–0.009, –0.004]PGSPAU I0.045[–0.063, 0.152]0.007[–0.093, 0.124] S0.035[0.006, 0.064]0.040[0.008, 0.072] Q–0.002[–0.004, –0.001]–0.002[–0.004, –0.001]Separation/discord I0.308[0.097, 0.518]0.128[0.032, 0.224] S–0.044[–0.099, 0.012]0.008[–0.019, 0.035] Q0.001[–0.002, 0.003]–0.000[–0.002, 0.001]Note: Polygenic score residualized on the first 10 genetic similarity principal components. Separate models were run for
