S0.182[0.128, 0.236]0.176[0.118, 0.234] Q–0.007[–0.009, –0.004]–0.006[–0.009, –0.004]PGSPAU I0.045[–0.063, 0.152]0.007[–0.093, 0.124] S0.035[0.006, 0.064]0.040[0.008, 0.072] Q–0.002[–0.004, –0.001]–0.002[–0.004, –0.001]Separation/discord I0.308[0.097, 0.518]0.128[0.032, 0.224] S–0.044[–0.099, 0.012]0.008[–0.019, 0.035] Q0.001[–0.002, 0.003]–0.000[–0.002, 0.001]Note: Polygenic score residualized on the first 10 genetic similarity principal components. Separate models were run for parental separation and parental relationship discord. All models included parental education as a covariate for initial status, whereas sex was included for both initial status and change over time. Boldface type indicates estimate p < .05. EA = European American; I = intercept; PGSPAU = problematic alcohol use polygenic score; Q = quadratic slope; S = linear slope.Table 4Linear Mixed Models Predicting Frequency of Heavy Episodic Drinking Across Time as a Function of Problematic Alcohol Use Polygenic Scores, Parental Separation, and Parental Discord in the African-Like (AA) SampleParental separation modelParental discord modeln = 887 (observations = 4,098)n = 463 (observations = 2,199)Parameterb95% CIb95% CIAge I–0.345[–0.569, –0.121]–0.285[–0.461, –0.110] S0.194[0.126, 0.264]0.191[0.147, 0.234] Q–0.007[–0.010, –0.003]–0.006[–0.008, –0.004]Sex, male I–0.151[–0.384, 0.082]–0.154[–0.399, 0.091] S0.095[0.026, 0.165]0.085[0.022, 0.149] Q–0.002[–0.006, 0.001]–0.001[–0.004, 0.003]PGSPAU I0.012[–0.108, 0.131]0.012[–0.120, 0.143] S–0.000[–0.037, 0.036]0.007[–0.027, 0.042] Q0.000[–0.002, 0.002]0.000[–0.001, 0.002]Separation/discord I–0.021[–0.261, 0.218]–0.068[–0.180, 0.043] S0.013[–0.060, 0.086]0.062[0.034, 0.090] Q0.000[–0.004, 0.004]–0.003[–0.004, –0.001]Note: Polygenic score residualized on the first 10 genetic similarity principal components. Separate models were run for parental separation and
