Signatures of parent-child relationship on both the reward and stress systems are left during development [53]. The association between alcohol misuse and disrupted early life social interactions between the parent and offspring is presumably driven, in part at least, by interactions with genes related to stress reactivity and emotion processing [16]. Parent-child relationship was here studied in relation to FKBP5 genotype and problematic alcohol drinking in young male adults. The TT genotype, in the presence of a poor relationship between the child and the parents, was associated with problematic drinking.
