Variants in the 11 genes known to cause extreme early-onset obesity also may contribute to milder forms of obesity [61], [62]. None of the genotyped variants in genes for monogenic obesity reached genome-wide significance in our GWAS, although several variants in CRHR1, CRHR2, MCHR1, MC3R, MC4R and POMC were nominally associated. Similarly, variants in or nearby the susceptibility genes for obesity did not attain genome-wide significance but several - CHST8, KCTD15, MTCH2, SFRS10, SH2B1 and TMEM18 - were nominally associated with obesity-related traits, consistent with GWAS in children of European-American [63] or European ancestry [9]. The lack of genome-wide significant findings for monogenic causes of obesity or susceptibility genes may be a function of our sample size and statistical power, or the presence of rare variants in the Hispanic population not represented in the Illumina platform.
