Throughout the entire process, significant emphasis is placed on using a robust set of standard operating protocols (SOPs) developed by DrugBank's senior curators. Currently, this set of SOPs spans hundreds of specific activities, describing in detail how to find, format and enter information into the DrugBank knowledgebase. New SOPs are added to mirror new data types or processes, and existing SOPs are kept up to date on a standard verification interval. All information entered by DrugBank curators at both the private (OMx Inc.) and public (University of Alberta) sites undergoes a secondary review by the curation team lead or other senior curators. Likewise, all changes made to the DrugBank knowledgebase are tracked in DrugBank's annotation system, and tagged to specific curators so that feedback can be provided in the case of error reports. Regular audits are applied to various aspects of the knowledgebase to ensure information currency.
