In the AA sample, 254 categories/pathways were observed to be enriched at p<0.05, 62 at p<0.01 and 6 at p<0.001. While there is some evidence for an excess of enriched categories at the less stringent significance levels (p=0.064 and p=0.052, respectively), this does not reach formal statistical significance. At an enrichment significance level of p<0.001, an excess of enriched categories is not observed (p=0.241). Applying pruning with K=0.5 increased the significance of the number of categories enriched at p<0.05 and p<0.01 (p=0.040 and p=0.034, respectively). There is thus some evidence for a biological basis to AD, captured by GO and KEGG annotations, in the AA sample. However, this evidence is not as strong as in the EA sample and a possible explanation may be due in part to the smaller AA sample.
