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Chunk #25 — Results — Gene Ontology Categories/KEGG pathways

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Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.
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In the supplementary data (Tables A3 and A4), we present the specific enriched GO categories/KEGG pathways corresponding to the most significant results in Table 4, at the category cutoff of p<0.01 for both samples. Thus, Table A3 contains those categories enriched at p<0.01 in the EA sample when pruning was applied with K=0.2, and Table A4 contains the GO categories/KEGG pathways enriched at p<0.01 in the AA sample when pruning was applied with K=0.5. The EA sample produced an excess of categories related to such diverse functions as response to hormone stimulus, membrane raft organization, anatomical structure homeostasis, phosphorylation, and regulation of transporter activity. GO categories observed in the AA sample included functions such as lipid catabolic processes, regulation of protein transport, regulation of cell adhesion, and cholesterol metabolic process. In tables A5 and A6, we present some of the individual GO categories for the top 5% of genes. These tables illustrate that genes may be functionally involved in several processes and therefore can occur in more than one GO category.