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Chunk #17 — Materials and Methods — fMRI acquisition, processing, and analysis

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Prefrontal response and frontostriatal functional connectivity to monetary reward in abstinent alcohol-dependent young adults.
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Preprocessed data sets were then analyzed using first-level random effects models that account for scan-to-scan variability and second-level random effects models that account for participant-to-participant variability to determine task-specific regional responses. For each participant and scan, condition effects (i.e., main effects of task) at each voxel were calculated using a t-statistic, producing a statistical image for the contrast of interest (i.e., win > loss).