× Alcohol interaction (β = −0.48, SE = 0.19, t = −2.49, p< .05), and an OPRM1 × Alcohol × Time interaction (β = 0.21, SE = 0.10, t = 2.00, p< .05). See Figure 3. Likewise, for Positive Mood there was a main effect of OPRM1 genotype effect (β = 0.60, SE = 0.26, t = 2.31, p< .05) and an OPRM1 × Alcohol interaction (β = −0.33, SE = 0.12, t = −2.49, p< .01). There was no OPRM1 genotype effect on alcohol-induced Sedation(OPRM1 × Alcohol:β = −1.74, SE = 2.02, t = −0.86, p = .39). Together, these results provide support for the initial hypothesis that OPRM1 genotype moderates the hedonic, but not the sedative, effects of alcohol.
