Among the SNPs with differential ASE, many showed the same direction of effect (p < 0.05) in more than one brain region (although the FDR might have been >0.05 in another region). For example, among the 92 SNPs with ASE in BLA that had FDR < 0.05 (no requirement for β12), 24 also showed changes in other brain regions (p < 0.05), of which 20 had consistent β12 direction in at least one of the other regions (Fig. 2c). Similar consistency was observed in significant SNPs (FDR < 0.05) in CE, NAC, and SFC (Supplementary Fig. 2). As shown in the heatmap (Fig. 2d), among the SNPs with FDR < 0.05 in at least one brain region, a similar trend of AUD-associated allelic bias was also observed in at least one other region.
