We used linear mixed models in SPSS v17 to test for main effects of classification method, time, medication group, 5-HTTLPR genotype, and their interactions on the number of drinking days and the number of heavy drinking days (defined as days on which men drank ≥ 5 standard drinks and women drank ≥ 4 standard drinks) per week during the 12-week study period. These are the same outcomes that were examined by Kranzler et al. (2011) in the initial analysis of the clinical trial of sertraline for AD, with subtyping based on age of onset of alcohol dependence as determined using the SCID. Hence, we present outcome data here only for the other two typologies (i.e., the cluster analytic and single item age-of-onset methods).
