that was found to be ameliorated by the histone deacetylase inhibitor valproic acid or the antipsychotic clozapine (Matrisciano et al., 2013). Altered GABAergic functioning occurs in schizophrenia and is thought to contribute to both positive and negative symptoms characteristic of the disorder (Guidotti et al., 2005; Guidotti et al., 2000). Taken together, these studies demonstrate the ability for prenatal stress to alter the epigenome and, in turn, produce schizophrenia-like symptoms in rodents.
