locomotor hyperactivity and decreased social interaction, both of which are behavioral indices of schizophrenia (Amann et al., 2010). As evidence for a link between these brain and behavioral implications of stress exposure, a positive correlation was found between social approach and Bdnf expression (Dong et al., 2015). Reelin, a gene implicated in the psychopathology of schizophrenia, was also reduced with a corresponding increase in DNA methylation of the Reelin promoter. These animals were hyperactive, had deficits in learning and memory, and displayed increased levels of anxiety as adults (Palacios-García et al., 2015). Another study found that decreased Reelin and glutamic acid decarboxylase 67 (GAD67) levels in adult mice with a history of prenatal stress were associated with overexpression of DNMTs in GABAergic neurons within the frontal cortex and hippocampus (Matrisciano et al., 2013). Further, increased methylation, hydroxymethylation, and MeCP2 and DNMT1 binding were observed at the Reelin and Gad67 promoters (Matrisciano et al., 2013). These animals displayed a schizophrenia-like phenotype that was found to be ameliorated by the histone deacetylase inhibitor valproic acid or the antipsychotic clozapine (Matrisciano et al., 2013). Altered GABAergic functioning occurs in schizophrenia and is thought to contribute to both positive and negative symptoms characteristic of
