Weiner et al. (2004) found that voluntary EtOH drinking is associated with a significant increase in paired-pulse plasticity at GABAergic synapses in dentate gyrus neurons from the hippocampal formation of monkeys (cynomolgus macaques), consistent with a reduction in GABA release probability. In addition, a lack of tolerance to the facilitating effects of both acute EtOH and flunitrazepam on the GABAA IPSCs was reported.
