studies also reported that chronic EtOH consumption induces tolerance to the impairing effects of acute EtOH treatment on induction of LTP in rat CA1 slices (Fujii et al. 2008). In CA1 slices from control rats, stable LTP was induced by tetanic stimulation, and LTP induction was blocked if the tetanus was delivered in the presence of 8.6 mM EtOH or muscimol. A decrease in the stimulation threshold for inducing LTP was found in hippocampal slices from chronic EtOH-treated rats. In addition, application of EtOH or muscimol did not affect LTP induction in these cells, suggesting that the effects of chronic EtOH exposure on LTP induction are mediated by a reduction in GABAergic inhibition in hippocampal CA1 neurons (Fujii et al. 2008).
