None of the SNPs in these genes, however, shows a significant association with schizophrenia after correction for only those SNPs in the 25 previously-associated candidate genes (n = 782). If we restrict our correction to only the SNPs within single candidate genes, however, then two of the genes contain SNPs that remain following gene-wide correction: FEZ1 (corrected for 13 SNPs) and NOTCH4 (corrected for 28 SNPs). The most strongly associated SNP in NOTCH4 (rs3134942, a synonymous coding SNP in very high LD with rs8192585, a nonsynonymous coding SNP) was actually the top hit in the Aberdeen cohort (p = 0.000016), but has not itself been implicated in other schizophrenia studies, and was not even marginally significant in the Munich dataset (p = 0.93).
