It has often been argued that associations in candidate genes with strong a priori hypotheses of disease involvement (due to previous association or due to biological plausibility) should be treated with more weight in a genome-wide association study than SNPs in other genes or in non-genic regions. We have therefore also reassessed a set of previously reported schizophrenia candidate genes with a less stringent correction for multiple testing [30]. For each gene we first checked whether a previously-associated candidate SNP itself (or a suitable proxy) showed any association in our cohort and secondly whether any SNP in the gene showed association in our cohort following correction for all the SNPs tested in the relevant gene (Table 2).
