LCA was performed in the SAGE sample with comparable results to the COGA sample, including probabilities of criteria endorsement. When examining class assignments of (a) SAGE subjects in the SAGE+COGA versus the primary SAGE sample, and (b) the 106 overlapping COGA subjects in SAGE (23 individuals were excluded in the COGA analysis due to the restriction on regular drinking), a McNemar's change test demonstrated no significant change in class assignment in the SAGE sample compared to SAGE+COGA nor in the 106 overlapping individuals (all p>0.72). Nine of the 10 SNPs with top association results in Table 4 were genotyped in the SAGE data, imputed dosage data was used for rs12006002, which had not been genotyped in SAGE. The SNPs did not demonstrate association with any of the phenotypes (all p>0.16).
