The DSM-IV criterion persistent desire/inability to cut down on drinking also exceeded genome-wide significance thresholds for rs11035102, in the olfactory receptor OR51L1 (olfactory receptor, family 51, subfamily L, member 1; p=7.3 × 10−8). Evaluation of imputed SNPs in this region revealed supporting evidence of genome-wide association for rs11035097 (p=8.3 × 10−8) in addition to moderate association with six other SNPs all in high LD with the genotyped SNP (r2≥0.80, all p<9.7 × 10−7). OR51L1 is located in a region of chromosome 11 with many other olfactory receptors (Figure 3B). The genotyped SNP also demonstrated suggestive association with drinking despite physical problems (p=2.1 × 10−6) and with the high-risk latent class probability trait (p=4.9 × 10−5).
