Of 84 BMI/obesity-associated CNVs catalogued from the literature, only 46 were detected in SAGE and only one, 16p12.3 deletion, was significantly associated with BMI. Speliotes et al. first reported the 16p12.3 deletion in a large-scale meta-analysis because a common BMI-decreasing allele was highly correlated with the same 21 kb deletion [9]. In the present study, the CNV was also moderately associated with obesity classes I and II. Additionally, two common CNVs on 1p36.1 and 5q13.2 were nominally associated with class II obesity. Our results did not yield additional support for the other BMI/obesity-associated CNVs, which might reflect limited power in the SAGE sample to detect the range of effect sizes, even when aggregate effects were considered. However, only 4 of the 84 CNVs identified from the literature have been associated with BMI/obesity in multiple studies. To that point, a recent study by Walters et al. attempted to replicate 18 BMI/obesity-associated CNVs and only replicated a rare 220 kb deletion on 16p11.2 [51]. Therefore, it is conceivable that the collections of CNVs examined here contained a greater number of false positives
