Finally, to determine if single hemisphere lesions differentially impacted the rats’ ability to inhibit behavior for movements made contralateral versus ipsilateral to the lesion we asked whether the percent correct and time needed to accurately perform STOP-change trials differed between the two directions. For percent correct, we found that rats with ACC lesions performed significantly worse on STOP-change trials for both contralateral (t(718) = 2.4588; P = 0.0142) and ipsilateral (t(719) = 3.0394; P = 0.0025) responses. Next, we investigated whether responses made in the direction that was contralateral to the lesioned hemisphere of ACC were more impaired than responses made in the ipsilateral direction. We compared STOP-change reaction times (i.e., movement times on STOP-change trials minus movement times on GO trials) across treatment conditions for when the correct response required a movement that was either contralateral or ipsilateral to the lesion. We found that, in rats with ACC lesions, movements in the direction that was contralateral to the lesion took significantly longer to redirect on STOP-change trials (t(718) = 2.8404; P = 0.0046), but no differences were observed when
