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Chunk #75 — Online Methods — Epigenetic analysis in human myeloid cell types

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A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease.
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We utilized HaploReg34 to annotate the regulatory element of the significantly associated SNPs and their tagging SNPs. The myeloid chromatin marks/states and PU.1 ChIP-Seq data at genetic loci were further examined through the Washington University Epigenome browser76 using the public Roadmap Epigenomics Consortium public tracks hub as well as custom track hubs for human monocytes and macrophages (hg19) (see URLs).