Finally it should be mentioned that we cannot exclude other relevant genes in the region like EPHX2. This gene encodes soluble epoxide hydrolase involved in xenobiotic metabolism by degrading potentially toxic epoxides. While EPXH2 is not one of the main metabolizers of THC, some involvement is possible, as soluble epoxide hydrolase may act on at least some endocannabinoid metabolites and metabolites of Δ8-THC44.
