by Lee et al. (2015), in which items are converted to z-scores before averaging. A higher score is indicative of a low level of response to alcohol (i.e., more drinks are required to feel the effects). The SRE is administered at three-year intervals beginning at age 12; we selected the first available score after the initiation of alcohol use to minimize confounding due to inaccurate memory. We also restricted analyses to the set of questions pertaining to an individual’s first five drinking occasions as we were interested in innate physiological responses to alcohol before tolerance developed (herein referred to as “SRE-5”). Thus, the timing of the SRE-5 assessment was contingent on each participant’s age of alcohol use initiation. Mean age at SRE-5 completion was 17.6 (SD 1.5, range 13.8–20.0). See also Supplemental Material.
