the stochastic nature of high throughput proteomic sequencing, the replication proteomes profiled 17 of the 19 proteins identified in the discovery PWAS. However, only 13 of these 17 proteins were heritable, with SNP-based heritability p<0.01, and were part of the replication PWAS (Table 2). A hypothesis-driven meta-analysis for these 13 genes using data from the discovery and replication PWAS revealed evidence for replication for 9 of the 13 genes (69% replication rate; Table 2, Supplementary Table 4). Here, replication was declared when the meta-analysis p-value was smaller than both of the p-values from the discovery and replication PWAS.
