identification of MICB in the PWAS necessitates further analysis of the MHC region in AN, such as the role of specific human leucocyte antigen types. Finemapped genes; MST1 (Chanda et al., 2016; Lu, Zhao, & Liu, 2020), PRKAR2A (Kong et al., 2016) and WDR6 (Lv, 2022) have previously been linked to inflammatory processes. Additionally, AN is also observationally associated with a pro-inflammatory state which includes increased levels of cytokines such as tumour necrosis factor and interleukins 1 and 6 (Caso et al., 2020; Dalton et al., 2018b; Gibson & Mehler, 2019). These studies are likely confounded by factors like reverse causality that complicates their interpretation, whilst there is evidence suggesting that some protein expression differences in severe AN may disappear after rehabilitation (Nilsson et al., 2020). Recent genetic studies suggest a protective effect of C-reactive protein (CRP) on AN, which may relate to infection susceptibility given that CRP is not simply a marker of inflammation (Reay et al., 2022; Tylee et al., 2018), as is often characterised, and directly participates in processes like phagocytosis (Dalton et al., 2018a; Del Giudice & Gangestad, 2018). Our data suggests that genes with immune related functions are involved in the pathogenesis of AN. Further
