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Chunk #57 — Methods — PAU PRS in independent samples. — UCL Core Exome Array.

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Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.
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Cases had an ICD-10 diagnosis of F10.2 (n = 637), including 324 individuals with a diagnosis of alcoholic hepatitis who had participated in the STOPAH trial and 313 subjects recruited from the AD arm of the DPIM study; controls were unrelated UK subjects from the UK Household Longitudinal Study (UKHLS; n = 9,189; neffective = 2,383). The sample was genotyped on the Illumina Human Core Exome Array (Illumina, San Diego, CA, US). GWAS QC was performed using standard methods and imputation was done using the HRC panel [67] on the Sanger Imputation server (https://imputation.sanger.ac.uk/). Association testing was performed with Plink1.9 [49].