Cases were identified with ICD-10 code F10.2 (n = 1,698) and comprised 492 individuals with a diagnosis of alcoholic hepatitis who had participated in the STOPAH (Steroids or Pentoxifylline for Alcoholic Hepatitis) trial (ISRCTN88782125; EudraCT Number: 2009013897–42) and 1,206 subjects recruited from the AD arm of the DNA Polymorphisms in Mental Health (DPIM) study; controls were UK subjects who had either been screened for an absence of mental illness and harmful substance use (n = 776), or were random blood donors (n-452; total n = 1,228; neffective = 2,851). The sample was genotyped on the Psych Array (Illumina, San Diego, CA, US). GWAS QC was performed using standard methods and imputation was done using the haplotype reference consortium (HRC) panel [67] on the Sanger Imputation server (https://imputation.sanger.ac.uk/). Association testing was performed using Plink1.9 [49].
