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Chunk #55 — Methods — PAU PRS in independent samples. — iPSYCH Group.

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Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.
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DNA samples for cases and controls were obtained from newborn bloodspots linked to population registry data [65]. Cases were identified with the ICD-10 code F10.2 (AD; n = 944); controls were from the iPSYCH group (n = 11,408; neffective = 3,487)). The iPSYCH sample was genotyped on the Psych Array (Illumina, San Diego, CA, US). GWAS QC, imputation against the 1,000 Genomes Project panel [46] and association analysis using the Ricopili pipeline [66] were performed. The current study is part of a general study in iPSYCH investigating the comorbidity of alcohol misuse and psychiatric disorders.