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Chunk #225 — VIII. A possible underlying neurobiology: connectivity constellations — B. Quality and/or quantity of connections involved in vulnerabilities

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.
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Quantitative morphometric studies have documented the large fraction of volume of cerebral cortical grey matter that is composed of “neuropil”, neuronal processes and their supporting/ensheathing glial elements [244, 245]. By comparison, vasculature and neuronal cell bodies contribute much less to the volume of grey matter. The ways in which neuropil and the neuronal connections that it contains 1) develop 2) change with experience (or disease) and 3) change with aging all provide interesting avenues for functional impact of individual differences in neuronal connections.