Further, when we compare the data from the sixty-four genes identified in both bioinformatic and hand searches with the data for the remaining 35 genes, strong cases can be made for inclusion of most of the remaining genes as “cell adhesion related”. CSMD1 and CSMD2, for example, represent two of the three currently-identified cub and sushi multiple domain genes, though they lack literature support for cell adhesion functions that is sufficiently strong to include them on the list of “bioinformatic search cell adhesion molecule genes”. Reviews and individual papers cite receptor protein tyrosine phosphatases as “cell adhesion molecules”, in ways that correspond to our hand annotation but not to their identification in the independent bioinformatic searches as cell adhesion molecules [239–243].
