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Chunk #39 — LIMITATIONS

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Deficits in functional connectivity of hippocampal and frontal lobe circuits after traumatic axonal injury.
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Given that the functional connectivity measures for this study are obtained from a resting state fMRI paradigm, it is not known whether patterns of connectivity during rest should correlate to functional or neurocognitive tasks. Consequently, it is possible the association between functional connectivity measures and outcome could be significantly different had synchronicity of BOLD signal between regions been measured during a cognitive task rather than during rest. Future studies may benefit from incorporating both resting state and task related functional connectivity measures in their design. It is also important to note that the results of this study are specific to functional connectivity patterns present six-months post-injury, as results may be different among a more acutely or more chronically brain injured sample.