A limitation of the present study is that the degree of compromise to interhemispheric white matter is not reported. Decrement in interhemispheric structural connectivity may account for degree of functional connectivity among patient populations, but DTI studies must be performed to measure the degree of structural compromise. It is highly recommended that diffusion tensor tractography (or similar analysis of diffusion tensor imaging data) be incorporated into the research design to more directly examine the association between the integrity of certain white matter structures, functional connectivity, and outcome. Another limitation of the current study, and any neuroimaging study in TBI has to do with heterogeneity inherent in TBI, as injury profiles including mechanism of injury, injury severity, and most importantly location of brain lesions can vary from patient to patient. Therefore, the results of this investigation may not be generalizable across traumatic brain injuries with different profiles.
