The SNPs in figure 2 are classified as significantly deleterious to protein function, and are in genes involved in the inflammatory response. However, none of these SNPs is known to produce a disease phenotype. We next illustrate how the KnowledgeNet can be used to investigate the complex relationships between the effect of these SNPs on protein function and the disease phenotype, through network level buffering against defective protein components. For simplicity, we consider one pair of genes with deleterious SNPs, Selectin E and selectin P. The sidebar on the SNP analysis page provides direct access to a wide range of information relevant to this question, including OMIM, pathways, GO annotation, mouse knockout results, and tissue specific expression data, and relevant abstracts. Clicking 'Gene Graph' in the left sidebar creates a Java window displaying the gene-gene relationships centered on SELE.
