A large amount of information is accessible through the Java interface. At the moment, we are specifically interested in possible buffering mechanisms that shield the phenotype from these deleterious SNPs. One such buffering mechanism is overlapping protein function, and many proteins with overlapping function are homologous [65]. Right clicking on the E-selectin node triggers a popup menu, including an option for highlighting all sequence homologs of that node in the graph. L-selectin and P-selectin are seen to be homologous to E-selectin, suggesting possible functional redundancy. The redundancy of selectins E and P is supported by the information obtained from the mouse knockout link in the same menu, which reveals that single mouse knockouts of each gene produce a mild phenotype, while the double knockout is severe [66]. Further support is provided by inspection of the expression profiles for the selectins, which shows a similar tissue specific pattern for Selectin E and selection P, with significant expression in multiple tissues, while selectin L is found in only a few tissues. Thus, an individual homozygous in either one of the deleterious SNPs
