Furthermore, in a recent study, Zhang and colleagues identified a genetic variant (rs61764370) localized in the 3′UTR of the Kirsten rat sarcoma viral oncogene homolog (KRAS) that interfered with miRNA/mRNA interaction, and increased risk of developing metastasis in osteosarcoma.71 Using several approaches, the authors demonstrated that the SNP interferes with the interaction between 3′UTR of KRAS mRNA and the miRNA let-7a, thus increasing KRAS protein level and influencing disease outcome.71
