(Table 1). Two consecutive chromosome 20 markers at 70.51 and 84.62 cM that had elevated LOD scores in adjusted parametric analyses also had elevated LOD scores in adjusted VC analyses (LOD = 1.07 and 0.95, respectively). Additional consideration of year at smoking maximum number of cigarettes further increased these chromosome 20 peaks (LOD = 1.39 and 0.98, respectively), though chromosome 1 peaks were further reduced (Table 1). Multi-point sex- and age-adjusted VC analyses yielded peak LOD scores of 1.71 (241 cM on chromosome 2) and 1.50 (84 cM on chromosome 20), but no LOD scores greater than 1.0 were observed on chromosomes 1, 11, or 17.
