Results of VC genome-wide linkage analyses are graphed in Figure 1 (lower graphs) as well. Five two-point LOD scores greater than 1.0 were observed, including three markers within 26 cM on chromosome 1: at 167.15 cM (LOD = 1.28), at 187.86 cM (LOD = 1.46), and at 193.02 cM (LOD = 1.13). Other elevated unadjusted LOD scores were seen on chromosome 7 at 62.68 cM (LOD = 1.10), and chromosome 17 at 138.03 cM (LOD = 1.12). Sex and age were found to be significant covariates in the VC model (p < 0.001). Adjustment for sex and age reduced the significance of the signal on chromosome 1 (Table 1), though a peak LOD score of 1.34 at 187.86 cM remained. Additional LOD scores greater than 1.0 in sex- and age-adjusted analyses were seen on chromosomes 2, 11, 17, and 20 (Table 1). Two consecutive chromosome 20 markers at 70.51 and 84.62 cM that had elevated LOD scores in adjusted parametric analyses also had elevated LOD scores in adjusted VC analyses (LOD = 1.07 and 0.95, respectively). Additional consideration of year
