From the other ontologies and pathways tested for enrichment in this study, some also exhibit similar trends in their empirical P-value distributions between the two study populations, of which several appear to be potentially meaningful to AD and neuronal function, including NOTCH → EP300 signaling (Gaino & Fishell 2002; Aguirre et al. 2010; Kaun et al. 2011), organic anion transport (Moonat et al. 2010), and calcium-dependent protein kinases (Yamauchi 2005; Lee & Messing 2008) (Fig. S6; Table S8). However it should be noted that many of the significant enrichment signals are indeed population-specific (Fig. S7 and S8), hinting that some important differences in the genetic etiology of alcoholism may exist between EAs and AAs.
