The second set of subjects included 11 sons of probands from the San Diego Prospective Study (SDPS) (Schuckit et al., 2005e). Their fathers had originally been selected between 1978 and 1988 as 18-to-25-year-old drinking but not alcohol-dependent sons of alcoholics and controls who were students or nonacademic staff at the University of California San Diego (Schuckit and Gold, 1988; Schuckit et al., 2005e). As part of the San Diego protocol, the original probands, their spouses, and all offspring age 12 and above have been followed every five years using interviews based on the SSAGA from the COGA protocol (Schuckit and Smith, 2000). During the 20-year-follow-up phase of the SDPS, drinking but not alcohol dependent offspring aged 18- to-29 years who lived in the San Diego area were identified and invited for a full SSAGA interview and to visit the alcohol challenge laboratory to participate in the same protocol used for their fathers 20 years previously. The 11 men reported on here were themselves subsequently followed-up during the next five-year family evaluation, and, thus, have data on the baseline drinking characteristics
