Chunk #152 — V. “Generalization” of selected genome wide association results between related disorders and phenotypes — A. Convergence between human genome wide association studies of dependence on a variety of addictive substances (Samples 1 – 6)
The “methamphetamine dependence” genes described above display convergence with genes identified by: a) clustered- positive results from genome wide association studies of polysubstance abuse in NIDA-MNB European- and African- American samples [12] b) nominally-positive SNPs from genome wide association studies of alcohol dependence [3, 33] and c) nominally-positive SNPs in comparisons of nicotine-dependent vs nondependent smokers [3]. Data from Samples 5 and 6 converge with these other addiction vulnerability datasets with Monte Carlo p values of a) 0.0412, b) 0.0016 and c) 0.0003, respectively.
