Since the discovery of Mendel’s law, genetic research has been challenged to identify genetic variants that contribute to human diseases. Along with the development of genome sequencing technologies, there have been impressive progresses within the research community over the past decade. Numerous methodologies have been developed and many disease-associated genes have been reported [87]. In this study, the work presented here embraces the recent development and addresses some of the research challenges in the field of genetic research. However, as we have seen, despite the promises of the solution we provide, it also prompts a great need to further investigate many of the issues we have presented.
