Chunk #32 — 2. Inhibitors of the NF-κB activation pathway — 2.8. Other mechanisms of NF-κB inhibition — 2.8.4. Anti-inflammatory and immunosuppressive agents
Several well known immunosuppressants are known to target NF-κB by distinct mechanisms, some precluding NF-κB nuclear translocation [181], some through inhibiting calcineurin [182], some by binding heat-shock proteins [183] and some by modulating the DNA binding or transactivation potential of NF-κB [184–187]. Examples of immunosuppressants having inhibitory effect on NF-κB activation include cyclosporin A (CsA) [181], FK506 [188, 189], PG490 (diterpene triepoxide) [187] and deoxyspergualin [183].
