No GWS loci emerged in the EA GWAS (Figure 1a; Supplemental Figure S1A). The lowest p-value (p = 8.6E-08; Table 2) was obtained for rs74611272, an intergenic SNP on chromosome 7. In contrast, three GWS regions were identified in the AA GWAS: on chromosome 3 (rs34066662: p = 1.77E-08 & rs58801820: p = 1.89E-08; Figure 1b; Supplemental Figure S1B), chromosome 13 (rs75168521: p = 3.31E-08 & rs78886294: p = 4.38E-08) and an insertion–deletion (indel) on chromosome 5 (5:141988181, mapped to rs527904740, p = 4.48E-08). As shown in Table 2, the effects of these variants were ancestry-specific. In addition, one locus on chromosome 1 was GWS in the trans-ancestral (EA+AA) meta-analysis (Figure 1c, Supplemental Figure S1C), with the most significant SNP, rs1890881 (p = 3.77E-08; EA p = 8.95E-05; AA p = 1.94E-05) in an intron of RABGAP1L (RAB GTPase Activating Protein 1 Like).
