Finally, we performed additional analyses with FUMA using additional mouse (n = 11) and human (n = 7) gene expression datasets to compare our findings and to assess consistency between species. We were able to identify at least one implicated cell type in 22 phenotypes (Fig. S26, Table S14). Using human gene expression data, 24 cell types were enriched in at least one phenotype, while using mouse scRNA data 70 cell types were revealed. Consistent with findings from 10x Genomics and KI datasets, pyramidal cells from various mouse brain regions, including pyramidal cells (CA1 and SS), were implicated in SCZ and cognitive performance. Pyramidal cells were also enriched in numerous psychiatric disorders, SUDs, and behavioral/quantitative phenotypes. Along with pyramidal cells, inhibitory GABAergic and MSNs were consistently enriched in psychiatric disorders, SUDs, and behavioral/quantitative phenotypes. Using human datasets, enrichment of pyramidal cells (CA1) was confirmed in SCZ, cognitive performance, intelligence, cross-disorders, and overall sleep duration. Additionally, pyramidal cells (CA1) were enriched in cigarettes smoked per day. However, the strongest consistent evidence was found for enrichment of GABAergic neurons from the prefrontal
