B) [PRS pt < 0.10: Odds-Ratio, OR = 1.21, 95% C.I. = 1.14 – 1.27, p = 1.29e-8]. The PRS was not significantly associated with the comparisons between those with no lifetime DSM5AUD vs. lifetime DSM5AUD but now low risk/abstinent (group C); OR = 1.09, 95% CI = 1.01 – 1.18, p = 0.028) or between those with active DSM5AUD/high-risk and those who were low-risk/abstinent; OR = 0.94, 95% CI = 0.86 – 1.02, p = 0.105). Because of this limited association with the PRS, the reduction/cessation measure was not carried forward into the conditional (controlling for rs1229984) follow-up analysis. DSM4AD and DSM5AUDSX were strongly correlated with maximum cigarettes smoked (p < 0.001) but alcohol consumption PRS were not predictive of maximum cigarettes smoked (N = 5,436, p = 0.67).
