As shown in Table 2, the alcohol consumption PRS predicted alcohol use, DSM4AD, and DSM5AUDSX at all pT, even after correction for multiple testing. It predicted the greatest variance in alcohol use (Δmarginal R2= 0.0139; PRS pT < 0.2), followed by DSM4AD (Δmarginal R2 = 0.0056; PRS pT < 0.01). DSM5AUDSX was also significantly associated with the PRS (Δmarginal R2= 0.0049; PRS pT < 0.5). MAXD was associated with the PRS at thresholds pt < 0.5 – 0.001 (maximum Δmarginal R2 = 0.0031), while SRE-T scores were only associated with the alcohol consumption PRS at pT < 0.1 (Δmarginal R2 = 0.0022). The results pattern for reduction/cessation of problem drinking suggests that the PRS were only associated with the difference between those with no lifetime DSM-5 AUD (group A) versus the group with active DSM-5 AUD and/or high-risk drinking (group B) [PRS pt < 0.10: Odds-Ratio, OR = 1.21, 95% C.I. = 1.14 – 1.27, p = 1.29e-8]. The PRS was not significantly associated with the comparisons between those with no lifetime DSM5AUD vs. lifetime DSM5AUD but now low risk/abstinent
