Despite this important conservation, most gene changes observed in the 11 week Cyp1b1-ko male mice on the LFD are substantially attenuated in the 36 week females. Notable examples include two glycogen-associated phosphatases (Ppp1r3 forms b and c) and the glucose transporter, Slc2a4, which were each stimulated in the males, but suppressed in the females. These changes in Cyp1b1-ko mice not only indicate a loss of differences between the groups, but substantial changes in hepatic energy regulation, despite the conserved suppression of triglyceride synthesis in the Cyp1b1-ko mice. We cannot, however, presently resolve the extent to which Cyp1b1 deletion is affecting aging or sexual dimorphism.
