Several psychiatric disorders and related traits were positively genetically correlated with AUDIT-P scores, including schizophrenia (rg = 0.22, p = 3.0 × 10−10), bipolar disorder (rg = 0.26, p = 1.5 × 10−4), ADHD (rg = 0.23, p = 1.1 × 10−5), and major depressive disorder (MDD, rg = 0.26, p = 5.6 × 10−3). Intriguingly, AUDIT-C was negatively correlated with MDD (rg = −0.23, p = 3.7 × 10−3) and ADHD (rg = −0.10, p = 1.8 × 10−2), whereas AUDIT-P showed positive genetic correlations with these same disease traits (rg = 0.26, p = 5.6 × 10−3; rg = 0.24, p = 1.1 × 10−5). We observed a positive genetic correlation between AUDIT-P scores and depressive symptoms (rg = 0.30, p = 3.0 × 10−8) and neuroticism (rg = 0.18, p = 2.6 × 10−4), and a negative genetic correlation with subjective well-being (rg = −0.24, p = 4.0 × 10−5).
