The themes identified in Aim I were then applied to the Latino focus group data gathered in support of Aim II, in order to provide insights into Latino perceptions on research participation involving biological samples, with special attention to content related to the collection of DNA. In addition to the 9 themes identified in the literature review, another theme emerged from the focus groups that can be conceptualized along the continuum of previous experience to no previous experience with research. For example, one female participant said “I did one study, about 9 years ago, when my daughter was diagnosed with Leukemia. They took blood, saliva, and urine, I want to say. And the reason why I did it, is I want to be able to help, so they can find what is causing that.” Table 2 provides a summary statement for each of the themes based on the data shared by focus group participants. In addition, sub-themes relevant to each topic are presented.